Laura McCabe is dealing Blackjack at Anubis Casino in Eagle Point, Indiana where she has worked for the last four years. She is called back to the office where she is shown an automatic card shuffling machine. She enjoys shuffling but now the machine will do it for her. She returns home and lets her cat, Dummy, out before making hard-boiled eggs. A fly buzzes around and she gets out a container of Git Gone spray and kills the fly. She takes the bottle of bug spray with her into the hot tub and closes the lid over her. She sprays the bug spray and inhales as long as possible, opening the lid when she can't breathe anymore.
Laura is dealing in the casino once again. Shadow Moon strolls up to her empty table and begins to play. He orders a drink and flirts with her as she deals. The server returns with his drink and as he reaches for it, he surreptitiously switches out his lower bet with higher chips to win more with his hand. The dealer's hand busts and Shadow scoops up the extra winnings. Laura confronts him when he tries to do it a second time and warns him about the cameras and undercover security that will arrest him. She tells him to finish his drink and leave.
After her shift, Laura walks through the parking lot to her car. Shadow approaches her and asks why she helped him. He continues flirting with her and tries to convince her to be his "inside man." She refuses and Shadow apologizes, asking to take her out for a drink. She says she just wants to go home so he tells her to take him home. They go home and have sex.
Laura wakes up the next morning to Shadow sitting in her kitchen drinking coffee and shuffling cards. He is impressed with Laura's card handling skills and begins teaching her some card tricks. They start dating and Laura introduces him to her friends, Audrey and Robbie Burton. One night, Laura asks Shadow what would happen if he ends up in jail. They get into a discussion about the afterlife with Laura saying she doesn't believe in anything and that "life is just not that interesting." They get married and Shadow starts working with Robbie at the Muscle Farm teaching boxing while Laura continues working at the casino.
One morning, she wakes Shadow up and brings him into the dining room for a conversation. She tells him she has thought it through and has figured out a fool-proof plan to rob the Casino. She explains that she is not happy, living in the same town she grew up in, in her grandma's house, and they both have shitty jobs. She has worked at the casino for eight years and has come up with the perfect plan where he won't get caught.
Laura visits Shadow in prison, asking how he got caught. She wants to make a deal and take part of the blame so they both get three years with a year and a half in prison. Otherwise, Shadow alone would end up with six years in prison, getting out in three. He refuses the deal and asks her if she can wait for him. She tells him she can.
Every time the phone rings from Woodward Federal Correctional Institution, Laura answers and accepts the collect call from Shadow. She spends time with Audrey and Robbie and visits Shadow in prison. She returns home one night to find Dummy dead on the floor. She calls Robbie and drinks wine while he buries Dummy in the backyard. He offers for her to come crash on their couch for the night but she refuses. She goes to him for a hug, which turns into a kiss. Laura pulls away, saying she is drunk and alone and her cat just died. They start kissing again. The next day, Robbie comes over to Laura's house with a fake excuse. Laura makes it clear that she is waiting for Shadow before they go inside to have sex.
Laura accepts a collect call from Shadow five days before he is to be released from prison. He has an uneasy feeling about a storm coming. She reveals to him that she and Robbie are planning a surprise party for his homecoming. Robbie is lying naked on Laura's bed. She hangs up with Shadow and they go on a drive in Robbie's car.
Robbie wants to leave Audrey for Laura but Laura tells him it is over because Shadow is coming home. She breaks it off with him, giving him a blowjob as he sings The Weight along with the radio. Laura's knee accidentally knocks the gearshift just as Robbie swerves to avoid an oncoming car. Their car ends up in a ditch with their bodies strewn along the highway.
Laura looks down on the crash site in shock before the landscape changes into a desert and Anubis appears. Anubis explains that she is now dead and leads her to his scales. He places a feather on one scale and reaches for her heart. Laura slaps his hand away and pushes down the scales as she tells him that her heart is heavier than the feather. Anubis leads her to her hot tub and tells her she will go to darkness because she believed in nothing. She starts to argue but he tells her he won't even remember her just as she is yanked out of the afterlife.
She digs herself out of her grave and vomits up formaldehyde . Everything is gray and blurry but she spots a golden light glowing in the distance and heads toward it. She finds it is coming from Shadow as he is being lynched by Technical Boy's Children. She runs to him, tearing apart the Children with superhuman strength. She jumps up to the rope hanging Shadow from the tree and breaks it so Shadow falls to the ground before proceeding to massacre the rest of the Children. As Shadow gets up off the ground, Laura hides from him.
Laura's right arm has come detached from her body and she is covered in blood. She walks home and takes a shower. She packs a bag of clothes, including the dress she was going to wear to Shadow's surprise party. She hears someone arriving before seeing the glowing light and realizes Shadow is there. She hides from Shadow in her hot tub.
In Audrey's craft room, Laura is trying to sew her arm back onto her body. She sees a scrapbook Audrey had made for Shadow as her stomach gurgles unpleasantly. Audrey shows up and sees Laura and starts screaming. She grabs her cell phone and locks herself in the bathroom as Laura begs her to not call the police. Laura breaks the bathroom doorknob and enters the bathroom as Audrey screams in the bathtub. She explains to Audrey that she needs to use the toilet and evacuates her bowels of embalming fluid. They discuss Laura and Robbie's affair and how everyone knows what happened. Audrey says it's easier "grieving someone when you're glad they're dead."
Audrey sews Laura's arm back on and Laura apologizes for fucking over Audrey. She admits the big lie she really told was that she promised Shadow she could wait for him. They leave in Audrey's car so Laura can find Shadow. Audrey tells Laura that Shadow deserves better than Laura and Laura admits that she loves Shadow now even though she might not have loved him before.
A black jackal and Mr. Ibis stand in the middle of the road, stopping Audrey's car. The jackal stands up into Anubis, telling Laura that he remembers her. Jacquel and Ibis take Laura to their funeral parlor. Ibis explains they have been in business for 200 years. They repair her with pins and threads and paint her skin. Jacquel asks if it was love that brought her back. She says it wasn't but it is now. Jacquel lets her know that when she is done, he will complete his task and deliver her into darkness.
Laura hangs fly paper in a motel room before changing into the dress she brought. She sits on the side of the bed and waits throughout the day and night. A golden light flashes past the window and Shadow opens the door, finding Laura waiting for him.